Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I† †Electronic supplementary information (ESI) available: Chemical synthesis and characterization of triptolide probes; Fig. S1–S10; Table S1–S3. See DOI: 10.1039/c5sc00633c Click here for additional data file.

Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I.

Peroxiredoxin I (Prx I) plays an important role in cancer development and inflammation. It is a dual-functional protein which acts as both an antioxidant enzyme and a molecular chaperone. While there have been intensive studies on its peroxidase activity, Prx I's chaperone activity remains elusive, likely due to the lack of chaperone inhibitors. Here we report that natural product triptolide se...

Isolation, structure and reactivity of a scandium boryl oxycarbene complex† †Electronic supplementary information (ESI) available: Synthesis, characterization of compounds 2 – 7. CCDC 981561–981563, 1042268 and 1042269. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc03138a Click here for additional data file. Click here for additional data file.

Experimental Section S3 Synthesis and Characterization of Scandium Boryl Carbene Complex (2) S4 Synthesis and Characterization of Phenylamido Enolate Complex (3) S4 13C-Labeled Experiments for Complex 3 S5 Synthesis and Characterization of Scandium Alkoxide Complex (4) S5 Synthesis and Characterization of Scandium Pyridyl Complex (5) S6 Figure S1. ORTEP drawings of 5 S6 Synthesis and Characteri...

Hydroxide-bridged five-coordinate DyIII single-molecule magnet exhibiting the record thermal relaxation barrier of magnetization among lanthanide-only dimers† †Electronic supplementary information (ESI) available: Synthetic procedures, structure, magnetism, ab initio calculation, magnetic interaction analysis, Fig. S1–S50, Table S1–S10, the crystal information files of compounds 1, 2 and 4. CCDC 1418657 for 1, 1418658 for 2 and 1506174 for 4. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc03621j Click here for additional data file. Click here for additional data file.

Beijing National Laboratory of Molecular Sc Engineering, State Key Laboratory of Applications, Peking University, Beijing, 100 edu.cn; [email protected]; Web: http://w 6275-1708 Jiangsu Key Laboratory for NSLSCS, Scho Nanjing Normal University, Nanjing 210023 Department of Chemistry, Key Laboratory (MOE), State Key Laboratory of Elem Innovation Center of Chemical Science University, Tianjin 30...

Systematic re-evaluation of the bis(2-hydroxyethyl)disulfide (HEDS) assay reveals an alternative mechanism and activity of glutaredoxins† †Electronic supplementary information (ESI) available: Alternative evaluation of the HEDS assay with ScGrx7 (Fig. S1), HEDS and GSSEtOH assay with PfGrx (Fig. S2), enzyme parameters for the GSSEtOH assay with ScGrx7 (Table S1) and calculations of estimated reaction velocities and substrate concentrations (Tables S2–4). See DOI: 10.1039/c5sc01051a Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.

Homochiral self-assembly of biocoordination polymers: anion-triggered helicity and absolute configuration inversion† †Electronic supplementary information (ESI) available: Preparation and physical characterization data of 1P and 2M, additional structural description, UV-Vis and CD spectra (Fig. S1–S7), crystallographic refinement details for 1P and 2M (Table S1), selected bond distances and angles for 1P and 2M (Tables S2–S5), ESI(+)-MS and ESI(+)-MSMS spectra (Fig. S8–S11 and Schemes S1 and S2) and PXRD (Fig. S12). CCDC 1046609 and 1046610. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc01089f Click here for additional data file. Click here for additional data file.